All concepts, explanations, trials, and studies have been re-written in plain English and may contain errors. I am not a doctor ----------------------------------------------------------- NOTE: You can make the print bigger with the font button on your browser! (It's usually a big "A") ---------------------------------------------------------- IMMUNOSUPPRESSANTS Also see www.ctsnet.org/doc/4510 antilymphocyte globulin (ATG, Atgam) azathioprine (Imuran) cyclosporine (Neoral, Sandimmune) Cytovene muromonab-Cd3 (Orthoclone) mycophenolate mofetil (CellCept) tacrolimus (Prograf) and emerging products such as Thymoglobulin Zenapax HLA Class I and Class II antigen testing HLA antibody screening PRA determination monoclonal antibody therapies DNA-based technologies ----------------------------------------------------------- Another immunosuppressants list : 15-Deoxyspergualin Allotrap Anti-CD11A Anti-CD45 Brequinar Sodium BTI-322 Budesonide Celsior CHI 621 CTLA4Ig Cyclosporine G FLT3 Ganciclover Gene-regulating Decoy generic azathrioprine generic cyclosporine Gusperismus Leflunomide MAK 195 F Orthoclone OKT4a PIC 060 Analogs ProGraf Promedrol Rapamune Thymoglobulin XE-9 Zenapax ----------------------------------------------------------- New compound regimens include: switching from cyclosporine to azathioprine 3 months after transplant New theories of immunotolerance include : Chimerism Transplanting bone marrow when implanting donor organ Gene therapy Manipulating T-cells Photopheresis Photochemotherapy/Photopheresis to treat positive crossmatch Signal II ----------------------------------------------------------- COMPANIES INVOLVED IN IMMUNOSUPPRESSANTS: Advanced Tissue Sciences C-Six Diagnostics, Inc. Collagen Corp. Cryolife, Inc. Cytotherapeutics Diacrin, Inc. Dynal, Inc. Fujisawa Pharmaceutical Co., Ltd. Gen Trak, Inc. Hoffmann-LaRoche Immunex Corp. LifeCell Corp. Medimmune, Inc. NexTran One Lambda, Inc. Organogenesis, Inc. Osteotech, Inc. Pel-Freez Clinical Systems Protein Design Labs, Inc. Sandoz Pharmaceuticals Corp. Sangstat, The Transplant Company. Wyeth-Ayerst